MIT Technology Review by Cassandra Willyard — Therapies to treat brain diseases share a common problem: they struggle to reach their target. The blood vessels that permeate the brain have a special lining so tightly packed with cells that only very tiny molecules can pass through. This blood-brain barrier “acts as a seal,” protecting the brain from toxins or other harmful substances, says Anne Eichmann, a molecular biologist at Yale. But it also keeps most medicines out. Researchers have been working on methods to sneak drugs past the blood-brain barrier for decades. And their hard work is finally beginning to pay off. Last week, researchers at the West Virginia University Rockefeller Neuroscience Institute reported that by using focused ultrasound to open the blood-brain barrier, they improved delivery of a new Alzheimer’s treatment and sped up clearance of the sticky plaques that are thought to contribute to some of the cognitive and memory problems in people with Alzheimer’s by 32%. For this issue of The Checkup, we’ll explore some of the ways scientists are trying to disrupt the blood-brain barrier. A patient surrounded by a medical team lays on the bed of an MRI machine with their head in a special focused ultrasound helmet

In the West Virginia study, three people with mild Alzheimer’s received monthly doses of aducanumab, a lab-made antibody that is delivered via IV. This drug, first approved in 2021, helps clear away beta-amyloid, a protein fragment that clumps up in the brains of people with Alzheimer’s disease. (The drug’s approval was controversial, and it’s still not clear whether it actually slows progression of the disease.) After the infusion, the researchers treated specific regions of the patients’ brains with focused ultrasound, but just on one side. That allowed them to use the other half of the brain as a control. PET scans revealed a greater reduction in amyloid plaques in the ultrasound-treated regions than in those same regions on the untreated side of the brain, suggesting that more of the antibody was getting into the brain on the treated side.

by Sean O’Kane — techcrunch — Hertz is selling off a third of its electric vehicle fleet, which is predominantly made up of Teslas, and will buy gas cars with some of the money it makes from the sales. The company cited lower demand for EVs and higher-than-expected repair costs as reasons for the decision. […]

by Brandon Vigliarolo – theregister — A mere 700 IT jobs were added in the US last year compared to 267,000 the year prior, it’s claimed. It’d be easy to blame layoffs, but that’s not all there is to it, says tech consultancy Janco Associates. Based on analysis of US Bureau of Labor Statistics data by Janco, news that the IT industry added just 700 jobs following an estimated 262,242 jobs lost amid mass layoffs is shocking, but not surprising. Yet while layoffs have generally kept IT job growth flat for the past year (2023’s net 700 comes despite more than 21,000 IT jobs being created in Q4), there’s still a surplus of vacant roles, with Janco finding some 88,000 remain open. “Based on our analysis, the IT job market and opportunities for IT professionals are poor at best,” said Janco CEO M Victor Janulaitis. “Currently, there are almost 100K unfilled jobs with over 101K unemployed IT Pros – a skills mismatch.”

In other words, while we’re definitely dealing with correction from pandemic overhiring, we’re also wading into a new paradigm where a lot of tech talent is going to have to retrain because AI is being crammed wherever C-level employees can stick it. A one-two punch to the IT jobs market Much of the layoff debt to hit IT jobs have come to entry-level positions, especially those in the customer service telecommunications and hosting automation areas. In turn, some of the responsibilities of those jobs are being reassigned to the latest and greatest AIs, says Janco.

Xerox prints pink slips for 15% of workforce Intel trims a few hundred workers in Cali just in time for Christmas 17% of Spotify employees face the music in latest cost-cutting shuffle Game over for ByteDance’s big video game studio dream? According to thge tech consultancy, entry-level IT demand is shrinking, though demand for those with AI, security, development, and blockchain skills remain desired. “Artificial Intelligence and Machine Learning IT Professionals remain in high demand,” said Janulaitis. Still, plans to further replace humans with AI workers at the entry level are hardly far-fetched, with multiple reports finding much the same.

By ASSOCIATED PRESS – Departure and arrival information was replaced by a message accusing the group of putting Lebanon at risk of an all-out war with Israel. The information display screens at Beirut’s international airport were hacked by domestic anti-Hezbollah groups Sunday, as clashes between the Lebanese militant group and the Israeli military continue to intensify along the border. Departure and arrival information was replaced by a message accusing the Hezbollah group of putting Lebanon at risk of an all-out war with Israel. The screens displayed a message with logos from a hardline Christian group dubbed Soldiers of God, which has garnered attention over the past year for its campaigns against the LGBTQ+ community in Lebanon, and a little-known group that calls itself The One Who Spoke. In a video statement, the Christian group denied its involvement, while the other group shared photos of the screens on its social media channels. “Hassan Nasrallah, you will no longer have supporters if you curse Lebanon with a war for which you will bear responsibility and consequences,” the message read, echoing similar sentiments to critics over the years who have accused Hezbollah of smuggling weapons and munitions through the tiny Mediterranean country’s only civilian airport. Hezbollah has been striking Israeli military bases and positions near the country’s northern border with Lebanon since Oct. 8, the day after the Hamas-Israel war in Gaza began. Israel has been striking Hezbollah positions in return.

The near-daily clashes have intensified sharply over the past week, after an apparent Israeli strike in a southern Beirut suburb killed top Hamas official and commander Saleh Arouri. In a speech on Saturday, Hezbollah leader Sayyed Hassan Nasrallah in a speech vowed that the group would retaliate. He dismissed criticisms that the group is looking for a full-scale war with Israel, but said if Israel launches one, Hezbollah is ready for a war “without limits.” Hezbollah announced an “initial response” to Arouri’s killing on Saturday, launching a volley of 62 rockets toward an Israeli air surveillance base on Mount Meron. The Lebanese government and international community have been scrambling to prevent a war in Lebanon, which they fear would spark a regional spillover. Lebanon’s state-run National News Agency said the hack briefly disrupted baggage inspection. Passengers gathered around the screens, taking pictures and sharing them on social media.

by Sharon Goldman — @sharongoldman – venturebeat — Disinformation concerns may be growing over the use of AI in the 2024 U.S. elections, but that isn’t stopping AI voice cloning startups from getting into the political game. For example, the Boca Raton, Florida-based Instreamatic, an AI audio/video ad platform that raised a $6.1 million Series […]

By Douglas Heaven — MIT review — This time last year we did something reckless. In an industry where nothing stands still, we had a go at predicting the future. How did we do? Our four big bets for 2023 were that the next big thing in chatbots would be multimodal (check: the most powerful large language models out there, OpenAI’s GPT-4 and Google DeepMind’s Gemini, work with text, images and audio); that policymakers would draw up tough new regulations (check: Biden’s executive order came out in October and the European Union’s AI Act was finally agreed in December); Big Tech would feel pressure from open-source startups (half right: the open-source boom continues, but AI companies like OpenAI and Google DeepMind still stole the limelight); and that AI would change big pharma for good (too soon to tell: the AI revolution in drug discovery is still in full swing, but the first drugs developed using AI are still some years from market).

Now we’re doing it again.

We decided to ignore the obvious. We know that large language models will continue to dominate. Regulators will grow bolder. AI’s problems—from bias to copyright to doomerism—will shape the agenda for researchers, regulators, and the public, not just in 2024 but for years to come. (Read more about our six big questions for generative AI here.) Instead, we’ve picked a few more specific trends. Here’s what to watch out for in 2024. (Come back next year and check how we did.)

Customized chatbots

By Brian Heater@bheate — techcrunch — r — MIT likens a new vibrating capsule to drinking a glass full of water prior to eating. Dieticians recommend the latter as a method for sending signals to your brain to simulate the sensation of being full. The researchers behind the new project further suggest it as a […]

By REBECCA ANNE PROCTOR — arabnews.com — DUBAI: As Saudi Arabia enters another busy event season, including grand city-based celebrations in Riyadh and Diriyah, a host of new entertainment ventures powered by new technology are opening up in the Kingdom. The latest move came in October when the Kingdom announced it was investing $55 million in HyperSpace, a three-year-old Saudi startup that designs digital theme parks within shopping centers. The funding came from Riyadh Season, a government-backed entertainment initiative under the Public Investment Fund, which provided most of the debt and equity raised by HyperSpace.

The other participants in the financing round included US-based Galaxy Interactive, Georgia SEGA Ventures and UK-headquartered Apis Venture Partners. “It’s really the world’s most innovative entertainment attraction,” Alexander Heller, the CEO of HyperSpace, told Arab News, adding: “It offers a completely new approach to location-based entertainment, as an attraction that is extremely innovative, built on technologies that already exist in the digital world and are being pulled into a physical front end for the first time.” Heller describes the attraction as like “TikTok and Fornite had a big physical baby.” He added: “It is part content creation arena and part physical video game. A park truly built on larger themes of content consumption, internet culture, and hype culture moving into a physical front-end entertainment space.”

HyperSpace features a mix of digital and physical entertainment, including gaming attractions, immersive theater experiences and interactive areas for content creation. The company opened its latest venue, House of Hype, in the capital city as part of the fourth edition of Riyadh Season, dubbed the world’s largest winter entertainment event. Bight and colorful phosphorescent lights greet guests, who enter several futuristically designed rooms in the new Riyadh House of Hype.

by Open AI :  — Aries: A year of growth and expansion. Aries natives can expect to experience positive changes in their career and personal life. They will have the opportunity to learn new skills and take on new challenges, which will help them grow both personally and professionally.

Taurus: A year of transformation and change. Taurus natives can expect to experience both positive and negative changes in their life. They may face some challenges, but these challenges will ultimately help them grow and transform into a better version of themselves.

Gemini: A year of self-discovery and personal growth. Gemini natives can expect to learn more about themselves and what they want out of life. They will have the opportunity to explore new interests and hobbies, which will help them grow and develop as individuals.

Cancer: A year of emotional healing and growth. Cancer natives can expect to work through some emotional issues and come out stronger on the other side. They will have the opportunity to heal old wounds and develop deeper connections with loved ones.

Leo: A year of creativity and self-expression. Leo natives can expect to tap into their creative side and express themselves in new and exciting ways. They will have the opportunity to explore new forms of self-expression, which will help them grow and develop as individuals.

by Emmy Lucas — Forbes Staff –– Job seekers are applying to more roles than years prior. Some say generative AI tools are to thank. Six months ago, Anshita Verma was sending out a handful of job applications a day. Now, the 26-year-old data scientist is sending out 10 to 15 daily, and she says it’s all thanks to artificial intelligence tools. “Instead of taking 30 minutes to fill out an application, it might take me 10,” says Verma. Plug-in AI browser tools that autofill the fields in job postings have greatly sped up the time she spends on applications, she says, letting her apply to more jobs more quickly.

Others are using generative AI programs like ChatGPT to create resumes and cover letters on demand that match the skills and qualifications of the job. Some are using job search automation tools such as LazyApply and SimplifyJobs to apply to jobs en masse. And AI tools such as Pyjama Jobs and Talentprise, which help candidates identify jobs their skill sets match, could also be boosting application rates. Experts say the tools are one reason, coupled with a cooler labor market and inflation, that employers are getting inundated with more applications. Workers in the U.S. and the U.K. are applying to about 15% more roles compared to a year ago, according to recent data from LinkedIn. “Job seekers are being more aggressive” compared to years past, says LinkedIn’s chief economist Karin Kimbrough, with AI helping people submit applications to more postings.

“There’s a whole energy around AI right now, and if you have these tools that are going to help you craft that perfect message with personalized suggestions, it really gives you a little bit more confidence in applying.” It can also prompt job seekers to apply more broadly. “Not only are they applying to more jobs, they’re actually applying to jobs they normally wouldn’t apply to,” says Michelle Volberg, founder and CEO of recruiting firm Giledan 360. “AI is like LinkedIn’s ‘Easy Apply’ tool on steroids. It’s letting tech candidates apply to finance or healthcare roles if there’s some sort of overlap, or make their resume appear relevant when in reality it’s not.”